Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements.

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2012-07

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Abstract

Depressed mood in pregnancy has been linked to low birth weight (LBW, 4,500 g) infants had 5.9% higher methylation at the PLAGL1 DMR compared with normal birth weight infants. Our findings confirm that severe maternal depressed mood in pregnancy is associated with LBW, and that MEG3 and IGF2 plasticity may play important roles.

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Humans, Pregnancy Complications, Birth Weight, Insulin-Like Growth Factor II, Cell Cycle Proteins, Tumor Suppressor Proteins, Transcription Factors, RNA, Untranslated, Sequence Analysis, DNA, Depression, DNA Methylation, Genomic Imprinting, Pregnancy, Adolescent, Adult, Infant, Newborn, Female, Male, Genetic Loci, High-Throughput Nucleotide Sequencing, RNA, Long Noncoding

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https://hdl.handle.net/10161/24661

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10.4161/epi.20734

Publication Info

Liu, Y, SK Murphy, AP Murtha, BF Fuemmeler, J Schildkraut, Z Huang, F Overcash, J Kurtzberg, et al. (2012). Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. Epigenetics : official journal of the DNA Methylation Society, 7(7). pp. 735–746. 10.4161/epi.20734 Retrieved from https://hdl.handle.net/10161/24661.

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