Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements.

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2012-07

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Abstract

Depressed mood in pregnancy has been linked to low birth weight (LBW, 4,500 g) infants had 5.9% higher methylation at the PLAGL1 DMR compared with normal birth weight infants. Our findings confirm that severe maternal depressed mood in pregnancy is associated with LBW, and that MEG3 and IGF2 plasticity may play important roles.

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10.4161/epi.20734

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Liu, Y, SK Murphy, AP Murtha, BF Fuemmeler, J Schildkraut, Z Huang, F Overcash, J Kurtzberg, et al. (2012). Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. Epigenetics : official journal of the DNA Methylation Society, 7(7). pp. 735–746. 10.4161/epi.20734 Retrieved from https://hdl.handle.net/10161/24661.

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