Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements.

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2012-07

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Abstract

Depressed mood in pregnancy has been linked to low birth weight (LBW, 4,500 g) infants had 5.9% higher methylation at the PLAGL1 DMR compared with normal birth weight infants. Our findings confirm that severe maternal depressed mood in pregnancy is associated with LBW, and that MEG3 and IGF2 plasticity may play important roles.

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Humans, Pregnancy Complications, Birth Weight, Insulin-Like Growth Factor II, Cell Cycle Proteins, Tumor Suppressor Proteins, Transcription Factors, RNA, Untranslated, Sequence Analysis, DNA, Depression, DNA Methylation, Genomic Imprinting, Pregnancy, Adolescent, Adult, Infant, Newborn, Female, Male, Genetic Loci, High-Throughput Nucleotide Sequencing, RNA, Long Noncoding

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https://hdl.handle.net/10161/24661

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10.4161/epi.20734

Publication Info

Liu, Y, SK Murphy, AP Murtha, BF Fuemmeler, J Schildkraut, Z Huang, F Overcash, J Kurtzberg, et al. (2012). Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. Epigenetics : official journal of the DNA Methylation Society, 7(7). pp. 735–746. 10.4161/epi.20734 Retrieved from https://hdl.handle.net/10161/24661.

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Murphy

Susan Kay Murphy

Associate Professor in Obstetrics and Gynecology

Dr. Murphy is a tenured Associate Professor in the Department of Obstetrics and Gynecology and serves as Chief of the Division of Reproductive Sciences. As a molecular biologist with training in human epigenetics, her research interests are largely centered around the role of epigenetic modifications in health and disease. 

Dr. Murphy has ongoing projects on gynecologic malignancies, including approaches to eradicate ovarian cancer cells that survive chemotherapy and later give rise to recurrent disease. Dr. Murphy is actively involved in many collaborative projects relating to the Developmental Origins of Health and Disease (DOHaD).

Her lab is currently working on preconception environmental exposures in males, particularly on the impact of cannabis on the sperm epigenome and the potential heritability of these effects. They are also studying the epigenetic and health effects of in utero exposures, with primary focus on children from the Newborn Epigenetics STudy (NEST), a pregnancy cohort she co-founded who were recruited from central North Carolina between 2005 and 2011. Dr. Murphy and her colleagues continue to follow NEST children to determine relationships between prenatal exposures and later health outcomes.

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