Platinum(II)-catalyzed intermolecular hydroamination of monosubstituted allenes with secondary alkylamines.

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A 1:1 mixture of (dppf)PtCl(2) and AgOTf (5 mol%) catalyzed the intermolecular hydroamination of monosubstituted allenes with secondary alkylamines at 80 degrees C to form allylic amines in good yield with selective formation of the E-diastereomer.





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Toups, Kristina L, and Ross A Widenhoefer (2010). Platinum(II)-catalyzed intermolecular hydroamination of monosubstituted allenes with secondary alkylamines. Chem Commun (Camb), 46(10). pp. 1712–1714. 10.1039/b925859k Retrieved from

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Ross A. Widenhoefer

Professor of Chemistry

Research in the Widenhoefer group is directed toward the development and mechanistic analysis of new organotransition metal-catalyzed transformations for application in the synthesis of functionalized organic molecules. In particular, our group has a long-standing interest in the functionalization of C–C multiple bonds with carbon and heteroatom nucleophiles catalyzed by electrophilic late transition metal complexes, with a recent focus on the synthetic and mechanistic aspect of gold(I) pi-activation catalysis. Current areas of inquiry include the following:

  1. Gold(I) and Pt(II)-catalyzed hydroamination of alkenes an allenes.
  2. Gold(I)-catalyzed dehydrative amination of underivatized allylic alcohols.
  3. Synthesis and study of cationic, two-coordinate gold pi-complexes.
  4. Evaluating the role of bis(gold) complexes in gold pi-activation catalysis.

More detailed descriptions of these research projects can be found at our group web page.

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