Age trajectories of physiological indices in relation to healthy life course.

Abstract

We analysed relationship between the risk of onset of "unhealthy life" (defined as the onset of cancer, cardiovascular diseases, or diabetes) and longitudinal changes in body mass index, diastolic blood pressure, hematocrit, pulse pressure, pulse rate, and serum cholesterol in the Framingham Heart Study (Original Cohort) using the stochastic process model of human mortality and aging. The analyses demonstrate how decline in resistance to stresses and adaptive capacity accompanying human aging can be evaluated from longitudinal data. We showed how these components of the aging process, as well as deviation of the trajectories of physiological indices from those minimising the risk at respective ages, can lead to an increase in the risk of onset of unhealthy life with age. The results indicate the presence of substantial gender difference in aging related decline in stress resistance and adaptive capacity, which can contribute to differences in the shape of the sex-specific patterns of incidence rates of aging related diseases.

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Citation

Published Version (Please cite this version)

10.1016/j.mad.2011.01.001

Publication Info

Arbeev, Konstantin G, Svetlana V Ukraintseva, Igor Akushevich, Alexander M Kulminski, Liubov S Arbeeva, Lucy Akushevich, Irina V Culminskaya, Anatoliy I Yashin, et al. (2011). Age trajectories of physiological indices in relation to healthy life course. Mech Ageing Dev, 132(3). pp. 93–102. 10.1016/j.mad.2011.01.001 Retrieved from https://hdl.handle.net/10161/14857.

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Scholars@Duke

Akushevich

Igor Akushevich

Research Professor in the Social Science Research Institute
Kulminski

Alexander Kulminski

Research Professor in the Social Science Research Institute
Kulminskaya

Irina Kulminskaya

Research Scientist, Senior
Yashin

Anatoli I. Yashin

Research Professor in the Social Science Research Institute

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