Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities.

Loading...
Thumbnail Image

Date

2020-10

Authors

Mainland, Joel D
Barlow, Linda A
Munger, Steven D
Millar, Sarah E
Vergara, M Natalia
Jiang, Peihua
Schwob, James E
Goldstein, Bradley J
Boye, Shannon E
Martens, Jeffrey R

Journal Title

Journal ISSN

Volume Title

Repository Usage Stats

83
views
166
downloads

Citation Stats

Abstract

The chemical senses of taste and smell play a vital role in conveying information about ourselves and our environment. Tastes and smells can warn against danger and also contribute to the daily enjoyment of food, friends and family, and our surroundings. Over 12% of the US population is estimated to experience taste and smell (chemosensory) dysfunction. Yet, despite this high prevalence, long-term, effective treatments for these disorders have been largely elusive. Clinical successes in other sensory systems, including hearing and vision, have led to new hope for developments in the treatment of chemosensory disorders. To accelerate cures, we convened the "Identifying Treatments for Taste and Smell Disorders" conference, bringing together basic and translational sensory scientists, health care professionals, and patients to identify gaps in our current understanding of chemosensory dysfunction and next steps in a broad-based research strategy. Their suggestions for high-yield next steps were focused in 3 areas: increasing awareness and research capacity (e.g., patient advocacy), developing and enhancing clinical measures of taste and smell, and supporting new avenues of research into cellular and therapeutic approaches (e.g., developing human chemosensory cell lines, stem cells, and gene therapy approaches). These long-term strategies led to specific suggestions for immediate research priorities that focus on expanding our understanding of specific responses of chemosensory cells and developing valuable assays to identify and document cell development, regeneration, and function. Addressing these high-priority areas should accelerate the development of novel and effective treatments for taste and smell disorders.

Department

Description

Provenance

Subjects

cell culture, olfaction, sniff, Congresses as Topic, Genetic Therapy, Humans, Olfaction Disorders, Regenerative Medicine, Small Molecule Libraries, Stem Cell Transplantation, Stem Cells, Taste Disorders

Citation

Published Version (Please cite this version)

10.1093/chemse/bjaa038

Publication Info

Mainland, Joel D, Linda A Barlow, Steven D Munger, Sarah E Millar, M Natalia Vergara, Peihua Jiang, James E Schwob, Bradley J Goldstein, et al. (2020). Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities. Chemical senses, 45(7). pp. 493–502. 10.1093/chemse/bjaa038 Retrieved from https://hdl.handle.net/10161/23367.

This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.

Scholars@Duke

Goldstein

Bradley John Goldstein

Professor of Head and Neck Surgery & Communication Sciences

Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.