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Application of a rank-based genetic association test to age-at-onset data from the Collaborative Study on the Genetics of Alcoholism study.

dc.contributor.author Li, YJ
dc.contributor.author Martin, ER
dc.contributor.author Zhang, L
dc.contributor.author Allen, AS
dc.coverage.spatial England
dc.date.accessioned 2015-09-21T01:08:52Z
dc.date.issued 2005-12-30
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/16451665
dc.identifier 1471-2156-6-S1-S53
dc.identifier.uri http://hdl.handle.net/10161/10631
dc.description.abstract Association studies of quantitative traits have often relied on methods in which a normal distribution of the trait is assumed. However, quantitative phenotypes from complex human diseases are often censored, highly skewed, or contaminated with outlying values. We recently developed a rank-based association method that takes into account censoring and makes no distributional assumptions about the trait. In this study, we applied our new method to age-at-onset data on ALDX1 and ALDX2. Both traits are highly skewed (skewness > 1.9) and often censored. We performed a whole genome association study of age at onset of the ALDX1 trait using Illumina single-nucleotide polymorphisms. Only slightly more than 5% of markers were significant. However, we identified two regions on chromosomes 14 and 15, which each have at least four significant markers clustering together. These two regions may harbor genes that regulate age at onset of ALDX1 and ALDX2. Future fine mapping of these two regions with densely spaced markers is warranted.
dc.language eng
dc.relation.ispartof BMC Genet
dc.relation.isversionof 10.1186/1471-2156-6-S1-S53
dc.subject Adult
dc.subject Age of Onset
dc.subject Alcoholism
dc.subject Chromosomes, Human, Pair 14
dc.subject Chromosomes, Human, Pair 15
dc.subject Cooperative Behavior
dc.subject Databases, Genetic
dc.subject Genetic Markers
dc.subject Genetic Predisposition to Disease
dc.subject Genetic Testing
dc.subject Humans
dc.subject Models, Genetic
dc.title Application of a rank-based genetic association test to age-at-onset data from the Collaborative Study on the Genetics of Alcoholism study.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/16451665
pubs.begin-page S53
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biostatistics & Bioinformatics
pubs.organisational-group Duke
pubs.organisational-group Duke Clinical Research Institute
pubs.organisational-group Duke Molecular Physiology Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group School of Medicine
pubs.publication-status Published online
pubs.volume 6 Suppl 1
dc.identifier.eissn 1471-2156


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