Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative.

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2005-09

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Abstract

The synthesis and structure-activity relationships (SAR) of salubrinal, a small molecule that protects cells from apoptosis induced by endoplasmic reticulum (ER) stress, are described. It is revealed that the trichloromethyl group greatly contributes to the activity. Based on the SAR results, salubrinal was converted into a biotinylated derivative which retains activity and can be used as a biological tool for target identification.

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10.1016/j.bmcl.2005.05.120

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Long, Kai, Michael Boyce, He Lin, Junying Yuan and Dawei Ma (2005). Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorganic & medicinal chemistry letters, 15(17). pp. 3849–3852. 10.1016/j.bmcl.2005.05.120 Retrieved from https://hdl.handle.net/10161/19705.

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Boyce

Michael Scott Boyce

Associate Professor of Biochemistry

The Boyce Lab studies mammalian cell signaling through protein glycosylation. For the latest news, project information and publications from our group, please visit our web site at http://www.boycelab.org or follow us on Twitter at https://twitter.com/BoyceLab.


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