Effects of Resistance Training on the Redox Status of Skeletal Muscle in Older Adults


<jats:p>The aim of this study was to investigate the effects of resistance training (RT) on the redox status of skeletal muscle in older adults. Thirteen males aged 64 ± 9 years performed full-body RT 2x/week for 6 weeks. Muscle biopsies were obtained from the vastus lateralis prior to and following RT. The mRNA, protein, and enzymatic activity levels of various endogenous antioxidants were determined. In addition, skeletal muscle 4-hydroxynonenal and protein carbonyls were determined as markers of oxidative damage. Protein levels of heat shock proteins (HSPs) were also quantified. RT increased mRNA levels of all assayed antioxidant genes, albeit protein levels either did not change or decreased. RT increased total antioxidant capacity, catalase, and glutathione reductase activities, and decreased glutathione peroxidase activity. Lipid peroxidation also decreased and HSP60 protein increased following RT. In summary, 6 weeks of RT decreased oxidative damage and increased antioxidant enzyme activities. Our results suggest the older adult responses to RT involve multi-level (transcriptional, post-transcriptional, and post-translational) control of the redox status of skeletal muscle.</jats:p>






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Publication Info

Mesquita, Paulo HC, Donald A Lamb, Joshua S Godwin, Shelby C Osburn, Bradley A Ruple, Johnathon H Moore, Christopher G Vann, Kevin W Huggins, et al. (n.d.). Effects of Resistance Training on the Redox Status of Skeletal Muscle in Older Adults. Antioxidants, 10(3). pp. 350–350. 10.3390/antiox10030350 Retrieved from https://hdl.handle.net/10161/29760.

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Christopher Vann

Postdoctoral Scholar

Dr. Vann is an exercise physiologist with a research focus centered in skeletal muscle physiology. His research focuses on elucidating mechanisms of tissue-to-tissue crosstalk and understanding how exercise-induced changes in epigenetic, genetic, and protein-level factors relate to health and performance outcomes across the age span. As rates of obesity, cardiometabolic disease, and sarcopenia increase in the U.S., Dr. Vann's research is centered on understanding the role of exercise in improved health outcomes at the molecular level and applying this knowledge to develop precise evidence based exercise interventions.

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